帕拉蛋白诱导的虚假高血症:两个病例的诊断陷
Nathan Lorde1,2, Guy Pratt3,4, Tarekegn Geberhiwot1,5,6
1Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Birmingham B15 2GW, UK.
偏蛋白可以干扰标准实验室测试,导致和维生素D水平虚假高. 替代测试方法证实这些结果是虚假的,防止不必要的患者治疗.
科学领域:
- 临床生物化学 临床生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 偏蛋白质是异常蛋白质,可以干扰实验室检测.
- 虚假的实验室结果可能导致误诊和不适当的患者管理.
研究的目的:
- 报告两个病例,其中帕帕蛋白导致血清和维生素D测量错误地升高.
- 突出认识到对患者的测试干扰的重要性.
主要方法:
- 对两名患者的临床生物化学结果的审查.
- 标准实验室测量与和维生素D的替代检测方法的比较.
- 鉴定由于类蛋白质的测试干扰.
主要成果:
- 标准测定表明,这两位患者的血清维生素D含量高和高血清维生素.
- 另一种测量方法显示,高的结果是虚假的.
- 鉴定出对蛋白质的存在是干扰的原因.
结论:
- 临床医生必须考虑对患者具有类蛋白或其他蛋白质异常的测试干扰的可能性.
- 对虚假结果的认识可以防止不必要的调查和治疗,保护患者的健康和资源.
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