抑制性细胞酸甲基化是病毒基因转移在不同的真核生物之间的一个标记物
Luke A Sarre1,2, Giselle Azucena Gastellou Peralta1,2, Pedro Romero Charria1,2
1School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.
Molecular biology and evolution
|July 25, 2025
概括
氨酸DNA甲基化在真核生物中主要使可移植元素和病毒元素沉默,而不是宿主基因. 这种古老的表观遗传机制,可能是通过横向基因转移获得的,早于复杂的基因调节.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 进化生物学 进化生物学
- 基因组学就是基因组学.
背景情况:
- 细胞因子DNA甲基化对于转移性元素 (TE) 沉默和真核生物中的基因调节至关重要.
- 它的祖先角色和进化起源在不同的血统中仍然不完全理解.
研究的目的:
- 为了重新评估DNA甲基转移酶的进化起源.
- 为了描述亚氨酸甲基化作用在未被充分研究的真核生物中,如Acanthamoeba castellanii,Cyanophora paradoxa和Naegleria gruberi.
主要方法:
- 对DNA甲基转移酶演变的分析.
- 在精选的真核生物物种中对DNA甲基化模式的表征.
- 甲基化区域与异色素标记的相关性 (H3K9me3,H3K27me3).
主要成果:
- 细胞DNA甲基转移酶具有丰富的祖先曲目,其中一些通过横向基因转移 (LGT) 获得.
- 研究物种的DNA甲基化被丰富在年轻的TE和沉默基因上,这表明主要的抑制功能.
- 甲基化区域与异色染色体标记相关,沉默的基因与病毒元素具有同质性.
结论:
- 氨酸甲基化很可能起源于作为一种机制来沉默可移植和病毒元素,可能来自细菌.
- 这种古老的沉默功能早于植物和动物中发现的基因体甲基化.
- 表观遗传信息对于理解真核生物基因组进化至关重要,包括LGT的影响.
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