在转移性癌症患者中推导和外部验证客观绩效状态
Eva Ruiz1, Christopher R Manz2, Anthony Girard3
1Medical Oncology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
JCO oncology practice
|July 25, 2025
概括
使用可穿戴加速度计的目标性能状态 (OPS) 准确地预测了转移性癌症患者的生存率. 这种新的方法为临床试验中传统的性能状态评估提供了可靠的替代方案.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
- 临床试验 临床试验
背景情况:
- 癌症患者的传统绩效状态 (PS) 评估可能是主观和不准确的.
- 通过可穿戴加速度计对身体活动的客观评估可以作为PS的可靠代理.
研究的目的:
- 通过可穿戴加速度计的日常体力活动数据来推导和外部验证客观性能状态 (OPS).
- 评估转移性癌症患者客观性能的状态和整体存活率之间的关联.
主要方法:
- 在两组转移性癌症患者中使用加速度计测量日常体力活动的前性测量.
- 根据平均每日行走的距离,根据生存分析和Youden指数推导OPS截止值.
- 使用多变量考克斯模型评估180天死亡率的OPS的外部验证.
主要成果:
- 一个OPS切断界限被定义为每天步行1200米.
- 较差的OPS在导出 (81.6%对38.4%) 和验证 (36%对8%) 队列中都与较高的180天死亡率显著相关.
- 低OPS的调整后危险比为6.82 (P < .001) 和7.07 (P = .02) 在分别导出和验证队列中.
结论:
- 来自体力活动的目标绩效状态 (OPS) 是一个独立的,外部验证的预后指标.
- 在癌症临床试验中,OPS可以作为传统PS评估的客观替代品.
- OPS可能有助于对转移性癌症患者的治疗决定.
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