基线和纵向变化峰值呼气流速作为老年人肉症的预测因素:一个为期4年的队列研究
Hui Qian1, Qifeng Chen2, Kangkang Chen2
1Rehabilitation Medicine Department, The Affiliated Hospital of Shaoxing University, Shaoxing, China.
The journal of nutrition, health & aging
|July 25, 2025
概括
较低的峰值呼气流率 (PEFR) 和其下降与老年人中较高的肉症风险有关. 改善PEFR可能会降低这种风险,这表明PEFR是肉症的早期标志物.
科学领域:
- 老年学是一门学科.
- 呼吸系统医学 呼吸系统医学
- 肌肉生理学 肌肉生理学
背景情况:
- 峰值呼气流速 (PEFR) 是简单的呼吸功能的测量.
- PEFR之间的关系,特别是随着时间的推移而发生的变化,和肉症风险的关系尚未得到充分理解.
- 随着年龄的增长而导致的肌肉损失 - - 萨尔科佩尼亚,是一个严重的公共卫生问题.
研究的目的:
- 调查基线PEFR及其纵向变化与老年人肉类的流行率和发病率之间的关联.
- 为了确定PEFR是否可以作为肉症风险的早期指标.
- 探索PEFR下降和改善对萨尔科佩尼亚发展的影响.
主要方法:
- 来自中国健康与退休长度研究 (CHARLS) 的数据分析,涉及5280名老年人.
- 基线PEFR和PEFR在2年的变化被评估与萨尔科佩尼亚诊断 (2019年AWGS标准) 相比.
- 采用多变量逻辑回归和离散时间比例危险模型,对混因素进行调整.
主要成果:
- 基线PEFR的1-SD降低与普遍的肉症患病率增加56%有关.
- 较低的基线PEFR (<80%预测) 显示,患有 Sarcopenia 的几率高出93%.
- 纵向PEFR下降与4年内 Sarcopenia发病率的增加有关,而改善显示了保护作用.
结论:
- 降低基线PEFR及其随着时间的推移的下降是老年人患上皮症的重要危险因素.
- 提高PEFR与降低了沙科佩尼亚风险有关.
- 皮肤污染指数 (PEFR) 成为老年人群中肉症风险的潜在,实用和可访问的早期预警信号.
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