时间限制的养可以通过抑制肠道微生物群的变化来防止类似抑郁症的行为
Shintaro Tsukada1, Kohki Matsubara2, Shoko Oba3
1Department of Rehabilitation Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; Department of Physical Therapy, Toyohashi SOZO University School of Health Sciences, Toyohashi, Japan.
Biochemical and biophysical research communications
|July 25, 2025
概括
时间限制饮食 (TRF) 预防由高脂肪饮食 (HFD) 引起的抑郁和肥胖. 在小鼠中,TRF减轻了HFD诱导的肠道炎症,大脑变化和抑郁行为.
科学领域:
- 营养和新陈代谢 营养和新陈代谢
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 长期高脂肪饮食 (HFD) 摄入促进肠道失调和炎症,与代谢功能障碍和抑郁症有关.
- 已知时间限制养 (TRF) 可以抵消HFD诱导的体重增加和肠道炎症.
- 对于TRF对HFD诱导的抑郁症的具体影响仍然不完全理解.
研究的目的:
- 调查TRF在预防抑郁症和由HFD引起的相关生理变化的有效性.
- 为了检查TRF对肠道微生物组成,大脑炎症和新陈代谢标志物的影响,小鼠食HFD.
主要方法:
- 在为期8周的干预中,小鼠被分配到三个组:正常 (NC),随心所欲的HFD (FA) 和带有TRF (FT) 的HFD.
- 用行为测试来评估类似抑郁的行为.
- 免疫组织化学分析了大脑炎症 (微质,神经细胞).
- 测量了血清瘦素水平和便微生物群多样性.
主要成果:
- 与NC相比,FA组表现出显著的体重增加和类似抑郁的行为,而FT组没有.
- HFD诱导大脑中激活的微质细胞和神经细胞增加,血清勒激素升高,肠道微生物多样性减少,FA组中抑郁症相关细菌增加.
- TRF (FT 组) 减轻了这些HFD诱导的大脑,血清瘦素和肠道微生物群的变化.
结论:
- HFD的摄入促进了肠道失调和神经炎症,导致肥胖和抑郁.
- TRF有效地预防HFD诱导的肥胖,肠道失调,神经炎症和抑郁行为.
- TRF代表了一种潜在的饮食策略,以减轻HFD对代谢和心理健康的不良影响.
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