多发性硬化症和肉症:从英国生物银行分析人口水平的患病率和关键风险因素
Matti D Allen1, Anthony Thompson2, Brian C Clark3
1Division of Neuromuscular Diseases, Department of Neurology, The Ohio State University, USA.
Multiple sclerosis and related disorders
|July 25, 2025
概括
患有多发性硬化症 (MS) 的人患上缩症和前缩症的风险明显更高,这些是与年龄有关的肌肉疾病. 与一般人群相比,他们也更有可能在生命的早期发展出前症.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 肌肉骨健康 肌肉骨健康
背景情况:
- 萨科佩尼亚和前沙科佩尼亚涉及与年龄相关的肌肉质量和功能下降,与健康状况不佳有关.
- 多发性硬化症 (MS) 和这些肌肉疾病之间的联系仍然不清楚.
研究的目的:
- 为了确定与没有MS的人相比,MS患者的前缩症和缩症的患病率.
- 为了调查与MS患者群体中前症相关的因素.
主要方法:
- 利用来自50多万参与者的英国生物库数据.
- 根据EWGSOP2标准 (低握力或低骨肌肉指数) 定义的萨尔科佩尼亚/前萨尔科佩尼亚.
- 在MS患者和普通人群之间比较的患病率.
主要成果:
- 与普通人群相比,患有多发性硬化症的个体患上了显著更高的肉症 (1.1%vs0.3%) 和前肉症 (14.1%vs7.2%).
- 高龄和低身体质量指数 (BMI) 与增加前缩症风险有关.
- 女性的性别与更高的前缩症患病率有关,而男性的性别显示患病率下降.
结论:
- 患有多发性硬化症的人面临着患上前缩症或缩症的风险大幅增加.
- 在患有多发性硬化症的个体中,前性硬化症可能在生命的早期表现出来.
- 低BMI和女性性别被确定为MS群体中前缩症的危险因素.
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