睡眠规律与认知功能有关,并且与血清大脑衍生的神经营养因子呈现反转的U形关系
Yue Cao1, Jaehee Lee1, Jaehoon Seol2
1Graduate School of Comprehensive Human Sciences, Doctoral Program in Physical Education, Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8574, Japan.
Sleep medicine
|July 25, 2025
概括
通过睡眠规律指数 (SRI) 测量的一致睡眠模式与更好的认知功能有关. 保持平衡的SRI可能会支持大脑健康,并可能减缓阿尔茨海默病的进展.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 睡眠科学 睡眠科学
背景情况:
- 睡眠模式越来越多地被认为对认知健康和神经退行性疾病 (如阿尔茨海默氏症) 的影响.
- 睡眠不规则对认知功能和来自大脑的神经营养因子 (BDNF) 的具体影响仍未得到充分研究,特别是在主观认知和睡眠问题的人群中.
研究的目的:
- 研究日常睡眠规律与认知功能之间的关联.
- 为了检查睡眠规律与血清BDNF水平之间的关系.
- 在一群相对健康的老年人中探索这些关联,他们对认知和睡眠有主观的担忧.
主要方法:
- 分析了458名参与者 (平均年龄65.0±11.1岁) 来自筑波幸福生活研究 (2023-2024,日本).
- 睡眠规律性是使用睡眠规律性指数 (SRI) 来量化,该指数来自24/7的动图.
- 认知功能通过综合电池进行评估,血清BDNF在子组 (n=232) 中进行测量.
主要成果:
- 较高的SRI分数在调整共变量后与更好的全球认知功能有显著的关联.
- 在SRI和血清BDNF水平之间发现了一个非线性,反转的U形关系.
- 与SRI平衡的参与者 (中等范围) 相比,与SRI低的参与者相比,血清BDNF水平显著更高.
结论:
- 睡眠规律,如SRI所示,是维持老年人认知功能的关键因素.
- 均衡的睡眠模式,避免过度硬和高不规则,可能对认知健康有益,并可能影响阿尔茨海默病的进展.
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