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孕产妇暴露于空气温度和小,易受伤害的新生儿的风险:确定关键窗口

Mingzhao Huang¹, Jian Fang¹, Yaqi Zhang¹

¹Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China.

Ecotoxicology and environmental safety

|July 25, 2025

概括

产前暴露于极端温度,无论是热还是冷,都会增加小脆弱新生儿 (SVN) 结果的风险,如早产和低出生体重. 特定的孕期窗口显示对温度波动的敏感性增加,强调需要进一步研究.

科学领域:

环境流行病学环境流行病学
围产期健康围产期健康
生殖毒理学生殖毒理学

背景情况:

小的易受伤害的新生儿 (SVN) 包括早产 (PTB),小的妊娠年龄 (SGA),和低出生体重 (LBW) 代表了一个重要的全球健康问题.
现有的关于产前温度暴露的研究缺乏确定关键发育窗口的时间精度.
这项研究调查了温度对SVN结果影响的精确时间.

研究的目的:

检查每周暴露于环境温度和小脆弱新生儿 (SVN) 结果之间的关联.
为了确定特定的孕期窗口,增加对极端温度的脆弱性.

主要方法:

一个回顾性队列研究1,129,572个单子出生在武汉,中国 (2011-2022).
每日环境温度数据 (分辨率为1公里2) 与母亲的居住坐标相关联.
扩展分布式滞后非线性模型 (扩展-DLNMs) 和后勤回归分析了每周温度-SVN关联.

主要成果:

14.5%的出生被归类为SVN (7.49%的PTB,4.66%的LBW,7.58%的SGA).
在怀孕期间暴露于热和冷都会增加SVN风险,主要是由PTB和LBW驱动的.
特定的热和冷暴露窗口与增加的PTB和LBW风险有关,对于每个结果和温度类型,在不同的妊娠周确定了峰值风险.

结论:

温度暴露和SVN结果之间的关系在整个妊娠期间遵循U形模式,但在不同发育阶段敏感度有显著的变化.
某些妊娠期更容易受到热的影响,而另一些则更容易受到寒冷的影响.
对胎盘和胎儿适应机制的进一步研究对于了解对极端温度的反应至关重要.

关键词:

怀孕的结果怀孕的结果在SVN SVN中使用.温度温度是指温度.每周暴露的每周暴露量

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