一个集群双重交叉试验早期与延迟的外表使用在机械通风,肠道养的患者
Yaodong Tang1, Glenn Eastwood1, Nuanprae Kitisin2
1Department of Intensive Care, Austin Hospital, Melbourne, Australia.
在接受肠道食的重症监护病房 (ICU) 患者中推迟外出治疗并没有改变腹的总体发病率. 然而,它确实延迟了腹的发作,这表明对这种常见并发症的影响有限.
科学领域:
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 在肠道食,输管和机械通风重症监护室 (ICU) 患者的外观使用是有争议的,因为相关的腹.
- 在这个易受伤害的患者群体中,出现时间对腹和相关并发症的影响需要进一步调查.
研究的目的:
- 评估药物服用的时间是否会影响肠道食,机械通风ICU患者的腹发病率和发病率.
- 评估早期与延迟的药物使用对二次结局的影响,如大肠,ICU停留时间和死亡率.
主要方法:
- 进行了一个集群,双交叉,随机试验,涉及机械通风,肠道养的成年人.
- 患者被分配到早期的外表使用 (肠道食的第1天) 或延迟的外表使用 (肠道食的第6天).
- 贝叶斯分析用于分析主要结果 (腹发生) 和次要结果.
主要成果:
- 腹的总体发病率在延迟 (42.4%) 和早期 (44.9%) 出生的组之间是相似的.
- 腹发作在延迟出现组显著延迟.
- 6天后腹的发生率在延迟出现组 (21.2%与44.9%) 显著降低.
结论:
- 在临重病的肠道食患者中,食的时间并没有显著改变腹的总体发生率.
- 推迟药物的服用有效地推迟了腹的发作.
- 这些发现表明,虽然延迟出现的症状可能不会减少整体发病率,但它可以减轻这种患者队列中腹的时间.
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