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尼日利亚草药制剂中聚二乙醇的发生,来源和人类健康风险评估
Chukwujindu M A Iwegbue1, Jane Oghenevwogaga2, Grace E Obi-Iyeke3
1Department of Chemistry, Delta State University P.M.B 1, Abraka, Nigeria; Advance Research Centre, Delta State University P.M.B 1, Abraka, Nigeria.
概括
在尼日利亚的草药制剂中测量了聚二乙烯 (PBDE). 该研究没有发现与它们的使用相关的显著致癌或非致癌风险.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 聚二乙烯 (PBDE) 是持久性有机污染物,具有潜在的健康风险.
- 草药制剂 (HMP) 被广泛使用,但它们与PBDE的污染情况尚不清楚,特别是在尼日利亚等地区.
- 了解健康医师的PBDE水平对于公共健康和安全至关重要.
研究的目的:
- 量化尼日利亚口服使用的HMP中39种PBDE原体的度.
- 分析PBDE在这些HMP中的同类分布模式.
- 评估与使用PBDE污染的HMP相关的潜在终身致癌和非致癌风险.
主要方法:
- 气色谱-质谱法 (GC-MS) 用于精确量化PBDE同源物.
- 采集和分析了尼日利亚各种口服应用的健康药物的样本.
- 根据量化的PBDE度进行了风险评估计算.
主要成果:
- 在HMP中,39个PBDE原体 (Σ39 PBDE) 的总度在2.00至312 ng g-1之间,平均值为55.6 ng g-1.
- 低含量的PBDE (单,二,三PBDE) 是主导的,这表明植物代谢和加工诱导的除.
- 风险评估表明,使用这些HMPs没有终身致癌或非致癌风险.
结论:
- 尼日利亚评估的HMP含有可检测的PBDE含量,其中较低的化同源占主导地位.
- 观察到的PBDE概况表明,环境和加工对其在HP中存在的影响.
- 在研究的健康医生中,目前的PBDE水平对终身暴露的用户不构成重大健康风险.
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