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LpxC 抑制剂对生产卡巴酶的Citrobacter spp. 的活性临床分离物临床分离物

Víctor Vinuesa¹, Raquel Cruces¹, Javier E Cañada-García²

¹Intrahospital Infections Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain.

Journal of global antimicrobial resistance

|July 25, 2025

概括

对于抗生素耐药性Citrobacter感染,LpxC抑制剂显示出有前途的作用. LpxC-4是最强的,而CHIR-090显示出杀菌作用,并防止Citrobacter spp.的再生. 临床分离物.临床分离物.

科学领域:

微生物学微生物学
药物发现药物发现药物发现
抗微生物耐药性抗微生物耐药性

背景情况:

这是一种Citrobacter spp. 是常见的肠道细菌,也是抗生素耐药性感染的来源.
LpxC酶抑制剂对格兰阴性细菌有效,但它们的活性在Citrobacter spp. 这不是很成熟的.
产生碳酶的Citrobacter spp. 种类. 构成严重的公共卫生威胁.

研究的目的:

评估LpxC抑制剂对产生卡巴酶的Citrobacter spp.的抗菌活性. 临床分离物.临床分离物.
描述LpxC抑制剂的强度和杀菌活性.
评估LpxC抑制剂之间的潜在交叉耐药性.

主要方法:

确定了61种临床Citrobacter spp.的最小抑制度 (MIC). 使用LpxC-2,LpxC-4和CHIR-090.0的分离物.
进行了两种Citrobacter spp.的时间杀戮测试. 菌株表现出不同的LpxC抑制剂MICs.
分析了针对A,B和D类卡巴酶分离物的活性.

主要成果:

LpxC-4表现出最高的强度,MIC90为0.5 mg/L.
这三种LpxC抑制剂都对Citrobacter spp.表现出类似的活性. 有不同类型的碳烯酶分离物.
在24小时内,LpxC抑制剂在4倍MIC时表现出杀菌活性,在1/4倍MIC时没有活性.

结论:

LpxC-4是一种强有力的抑制剂,而CHIR-090显示出快速的杀菌作用,并防止再生.
结构相似的LpxC抑制剂显示出中度的交叉耐药性.
LpxC 抑制剂代表了一种潜在的治疗策略,可以对抗产生卡巴酶的Citrobacter spp.

关键词:

抗生素耐药性抗生素耐药性碳烯质量衰减的原因这是一种Citrobacter spp.临床分离物临床分离物 LpxC 抑制剂的使用菌株系列系列菌株系列

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