在年轻成年人中,肌肉损伤性运动后,血管功能的氧化还原依赖控制的证据:一个随机的安慰剂对照试验
Georgios Mavraganis1, Alexandra Sakelliou1, Georgios Georgiopoulos2
1Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, 80 Vas. Sofias Str, Athens 11528, Greece.
概括
补充N-乙囊 (NAC) 可能会防止运动诱导的血管功能障碍. 这种抗氧化剂在高强度抵抗运动后减轻了内皮功能障碍,这表明氧化应激作用.
科学领域:
- 运动生理学 运动生理学
- 血管生物学 血管生物学
- 营养生物化学 营养生物化学
背景情况:
- 高强度的抵抗运动可以暂时损害血管功能.
- 这种功能障碍可能是由氧化和炎症过程介导的.
研究的目的:
- 调查N-乙囊 (NAC) 对运动诱导的血管功能障碍的保护作用.
- 为了评估氧化应激在强度异常运动后血管变化的作用.
主要方法:
- 随机,交叉,安慰剂对照研究与10名健康男性志愿者.
- 在异常运动后,每天服用口服NAC或安慰剂8天的恢复期.
- 测量包括脉冲波速度 (PWV) 和流介扩张 (FMD).
主要成果:
- 异常运动在48小时内显著降低了安慰剂组的口炎.
- 补充NAC可以防止口热的显著下降.
- 在两组中都没有观察到PWV的显著变化.
结论:
- 奇特的运动会诱导内皮功能障碍,可能是通过氧化应激.
- N-乙囊 (NAC) 减轻了这种运动诱导的内皮功能障碍.
- NAC可能是减轻运动后血管功能障碍的潜在治疗剂.
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