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加拿大安大略省北部的第一民族社区的长期暴露和认知功能

Donna Mergler¹, Aline Philibert¹, Jennifer Laura Lee¹

¹Université du Québec à Montréal, Centre de recherche interdisciplinaire sur le bien-être, la santé, la société et l'environnement (CINBIOSE), CP 8888, Succ. Centreville, Montréal, Québec H3C 3P8, Canada.

Neurotoxicology

|July 25, 2025

概括

长期暴露于工业排放中的 (Hg),即使是几十年后,也与成年人的认知缺陷有关. 当前的水平没有显示任何关联,表明继承暴露影响大脑功能在初始污染后很长时间.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
毒理学毒理学毒理学

背景情况:

工业 (Hg) 排放对健康有长期影响.
以前的研究将产前和儿童时期的Hg暴露与认知缺陷联系起来.
关于成年人暴露于的长期认知影响的数据有限.

研究的目的:

调查历史暴露与成人的认知功能之间的关联.
评估传统暴露对认知缺陷的影响.
为了区分过去与当前暴露对认知表现的影响.

主要方法:

在85名成年人 (32-75岁) 中分析蒙特利尔认知评估 (MoCA) 测试结果 (调整得分:MoCA-r).
对头发 (HHg) 度 (1970-1997) 和当前血液Hg水平的回顾性分析.
纵向混合效应模型 (LMEM) 用于建模HHg进化及其与认知得分的关联.

主要成果:

较高的历史最大HHg度与较低的MoCA-r得分有显著的关联.
受影响的认知领域包括语言流,抽象,认知灵活性,工作记忆和视觉空间功能.
目前血液中的Hg水平和认知表现之间没有发现任何关联,这表明最近的暴露对影响最小.

结论:

遗留的暴露可以导致持续数十年的认知缺陷.
成年人的认知功能受到过去高暴露的负面影响,即使当前水平较低.
需要进行前性研究,以了解认知能力下降的速度和持续暴露的未来影响.

关键词:

认知功能认知功能第一个国家第一民族.原住民族原住民水星水星水星水星水星这就是MoCA MoCA.

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