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中间前额叶皮层输入到背中条体,调节雄性小鼠轮子运行的动机

Kazuhei Niitani¹, Ryoma Nishida¹, Yu Ogura¹

¹Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.

Journal of pharmacological sciences

|July 26, 2025

概括

脊椎中条体 (DM-Str) 中的神经活动驱动动物轮子运行的动机. 这一活动由中间前额叶皮层投影调节,对于参与这种奖励行为至关重要.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
动物模型动物模型

背景情况:

轮子运行是动物的奖励行为,表明了重要的动机.
背中条体 (DM-Str) 涉及到驱使轮子运行的动机,但其因果作用尚不清楚.
了解动机背后的神经机制对于行为神经科学至关重要.

研究的目的:

调查神经活动在DM-Str中在驱使轮子运行的动机中的因果作用.
确定与这种动机相关的调节DM-Str活动的机制.

主要方法:

用GCaMP传感器进行光纤测量,以记录轮子运行期间的DM-Str神经活动.
在DM-Str中进行药理学操纵 (muscimol,NBQX),以评估对动机的影响.
开放的实地测试来评估运动运动活动.
中间前额叶皮层 (mPFC) 的化学基因抑制对DM-Str投射.

主要成果:

在开始跑步时,DM-Str神经活动增加,在跑步时减少.
通过GABA_A或AMPA受体操纵抑制DM-Str神经活动减少了轮子的运行,但不是一般的运动.
抑制mPFC到DM-Str投射降低了轮子的运行行为,而不会影响运动活动.

结论:

DM-Str神经活动对于调节驱使人去跑步的动机至关重要.
从mPFC到DM-Str的质质体投射增强了这种活动,对激励至关重要.
这些发现阐明了一个关键的神经回路,它是动物激发行为的基础.

关键词:

背中中间的条纹体纤维光度计是指光纤光度计.中部前额叶皮层中部前额叶皮层.动机动机动机轮子运行,轮子运行.

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