在形细胞疾病中使用大麻治疗慢性疼痛:一个范围广泛的评论
Simone B Jackson1, Isaac Payton1, Keesha Powell-Roach2
1Department of Biobehavioral Nursing Science, University of Florida, College of Nursing, Gainesville, FL.
概括
大麻和大麻素在控制状细胞疾病 (SCD) 疼痛方面显示出混合但总体而言是积极的结果. 需要进一步的研究来确定SCD患者的安全性和最佳剂量.
科学领域:
- 医学研究 医学研究
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 状细胞疾病 (SCD) 是一种遗传性血液疾病,会引起严重的疼痛.
- 目前用于SCD的疼痛管理策略存在局限性.
- 大麻和大麻素正在被探索为替代性疼痛缓解选择.
研究的目的:
- 系统地审查有关大麻和大麻类药物用于SCD成人疼痛管理的文献.
- 评估大麻和大麻素对SCD疼痛结果的有效性.
- 确定目前关于大麻使用在SCD的研究中的差距.
主要方法:
- 进行了系统的范围审查.
- 通过使用PubMed,CINAHL和Cannakeys数据库来确定研究.
- 纳入标准侧重于使用医疗或娱乐大麻治疗疼痛的成年SCD患者.
主要成果:
- 十二项研究符合纳入标准,对大麻素有效性的证据是混合的,但总体上是积极的.
- 一些研究报告说,吸入大麻可以降低疼痛得分.
- 注意到安全问题,特别是合成大麻素,并观察到住院治疗的结果各不相同.
结论:
- 尽管有混合证据,但大麻素可能为管理SCD疼痛提供潜在的益处.
- 没有研究表明大麻使用加剧了SCD症状.
- 建议制定个性化治疗计划,并进一步研究标准化剂量和长期安全性.
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