妊娠早期患有高血压疾病和妊娠期糖尿病的患者的肠道微生物群变化:一个前性队列研究
Zhihua Zuo1, Shanshui Zeng2,3, Xinyi Ou4
1Department of Clinical Laboratory, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China.
BMC pregnancy and childbirth
|July 27, 2025
概括
在妊娠20周之前改变的肠道微生物群,包括Actinobacteria和Bacteroidetes,可以预测妊娠糖尿病 (GDM) 和妊娠高血压障碍 (HDP). 这些早期的肠道微生物组变化先于临床诊断.
科学领域:
- 微生物组研究的研究.
- 孕产妇与胎儿的医学
- 代谢性疾病研究研究.
背景情况:
- 怀孕期间的代谢疾病,如妊娠期糖尿病 (GDM) 和妊娠中高血压疾病 (HDP),越来越引起临床兴趣.
- 早期识别GDM和HDP的风险因素对于改善母亲和胎儿的结果至关重要.
- 肠道微生物群在与怀孕相关的代谢障碍中的作用是一个新兴的研究领域.
研究的目的:
- 在怀孕第20周之前,调查孕妇患有GDM和HDP的肠道微生物群组成.
- 确定与GDM和HDP早期阶段相关的特定细菌种群.
- 评估肠道微生物群作为GDM和HDP早期诊断标记物的潜力.
主要方法:
- 未来的队列研究设计.
- 在怀孕20周之前收集的便样本的16S rRNA基因测序.
- 使用QIIME2和R的生物信息分析,比较GDM,HDP和健康怀孕组之间的微生物群.
- 后勤回归建模以评估GDM和HDP的诊断价值.
主要成果:
- 在健康怀孕和患有GDM或HDP的怀孕之间观察到肠道微生物群组成的显著差异.
- HDP组的Actinobacteria数量较高,Bacteroidetes的数量较低 (p < 0.05).
- GDM组表现出增加的Bacteroidetes丰度,而GDM和HDP组都有更高的Synergistes丰度.
- 动因细菌的丰富程度与GDM和HDP的不良发展有关.
- 后勤回归模型的AUC值为HDP的0.77和GDM的0.69.
结论:
- 在怀孕20周之前肠道微生物组合的改变先于GDM和HDP的临床诊断.
- 包括Actinobacteria, Bacteroidetes和Synergistes在内的特定细菌种类与早期GDM和HDP有关.
- 怀孕早期肠道微生物群分析提供了一种新的策略,用于识别有代谢障碍风险的女性.
- 这些发现凸显了肠道微生物组作为怀孕中的预测生物标志物的潜力.
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