肠道炎症和微生物群调制影响耳功能:对肠耳轴的新兴见解
Anna Pisani1, Valentina Petito2, Fabiola Paciello3,4
1Dipartimento di Neuroscienze, Unità di Audiologia, Università degli Studi di Napoli Federico II, Naples, 80131, Italy.
Cell communication and signaling : CCS
|July 27, 2025
概括
肠道炎症和肠道微生物群的改变会对听力敏感性产生负面影响. 通过便微生物种移植 (FMT) 恢复肠道微生物群可以保护和改善听觉功能,突出显示肠耳轴.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 肠道-微生物群-大脑轴已建立,但肠道-外周神经系统连接,特别是内耳连接,理解较少.
- 肠道炎症和肠道微生物群的改变可能会影响神经和潜在的感官功能.
- 调查肠内耳连接对于了解系统性疾病对听力的影响至关重要.
研究的目的:
- 为了研究肠道炎症对听觉敏感性的影响.
- 评估通过便微生物种移植 (FMT) 调节肠道微生物群对耳功能的影响.
- 探索与肠道健康相关的状中的分子和形态变化.
主要方法:
- 听觉脑干反应 (ABR) 用于评估DSS诱导的大肠炎或FMT的小鼠的听觉敏感性.
- 分析了耳组织的炎症,氧化应激和血液迷宫屏障的完整性.
- 测量了肠道微生物组成和全身炎症标志物 (LPS).
主要成果:
- 肠道失调与耳变化相关,包括增加氧化应激,炎症和血液迷宫屏障受损.
- 通过MyD88/NF-κB途径观察到巨细胞透和免疫激活在尾细胞中.
- 活跃性结肠炎患者的FMT加剧了耳问题,而缓解期患者的FMT对听力产生了保护作用.
结论:
- 肠道炎症和失生症会对内耳病理和听力敏感性产生负面影响.
- 肠道微生物群的治疗调节,正如FMT所示,可以积极影响听觉功能.
- 这些发现支持肠道微生物群内耳轴,其中肠道健康影响耳完整性和听力.
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