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Updated: Jun 14, 2026

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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开发和应用一种LC-MS/MS方法,用于量化人类和老鼠血中的米素

Christoph Pfaffendorf1, Keanu D Sackmann1, Johannes Mischlinger2,3,4

  • 1Institute of Pharmacy, Dept. of Clinical Pharmacy, University of Hamburg, Bundesstrasse 45, 20146, Hamburg, Germany.

Malaria journal
|July 27, 2025
PubMed
概括

一种新的LC-MS/MS方法在血中准确量化了抗疟疾药物米. 这项验证的试验支持治疗疟疾的米多辛的临床开发.

关键词:
生物分析是一种生物分析.斯米多米辛是一种菌.在 LCMS/MS 中使用.疟疾:疟疾是一种疾病.药理动力学 药理动力学

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MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...