上肢转移性骨病与下肢转移性骨病的差异性生存结果:一个追溯的比较队列分析
Chih-Wei Chen1, Chih-Chi Su1, Jyun-Hao Chen2
1Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Journal of orthopaedic surgery and research
|July 27, 2025
概括
下肢转移性骨病 (MBDex) 与较差的生存率有关. 手术干预改善了下肢MBDex的生存率,但对上肢MBDex没有那么显著.
科学领域:
- 在瘤学瘤学.
- 整形外科 整形外科 整形外科
- 手术研究的研究.
背景情况:
- 肢体转移性骨病 (MBDex) 显著影响患者的生活质量.
- 在MBDex中,手术干预的生存益处需要进一步澄清,特别是关于上肢与下肢的参与.
- 基于转移部位和治疗方式的生存结果的证据有限.
研究的目的:
- 根据转移部位 (上肢与下肢) 来评估MBDex患者的生存结果.
- 为了确定操作与非操作管理对MBDex生存的影响.
- 为了确定影响MBDex生存的预后因素.
主要方法:
- 在2010-2018年期间接受MBDex治疗的1,719名患者的回顾性队列研究.
- 包括20岁以上接受手术或非手术治疗的患者;不包括同时发生的上肢和下肢转移.
- 使用卡普兰-梅尔曲线和多变量考克斯回归模型进行生存分析.
主要成果:
- 与上肢MBDex相比,下肢MBDex患者表现较差,两年生存率较差.
- 操作管理与下肢MBDex的生存益处相关,上肢MBDex的益处不那么明显.
- ECOG表现状况,并发症,原发性瘤类型和白蛋白水平是常见的预后因素;全身治疗,内脏和大脑转移在较低的MBDex中是有害的.
结论:
- 下肢MBDex与较差的生存结果有关.
- 操作管理为下肢提供了生存优势MBDex.
- 区分上肢和下肢转移对于MBDex.ex的生存预测和分析至关重要.
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