使用共振雷利散射信号放大进行简化分析策略,用于纳米尺度量化含量评估片中的拉萨吉林
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut Branch, Al-Azhar University, Assiut, 71524, Egypt. Ahmedabuhassan@azhar.edu.eg.
BMC chemistry
|July 27, 2025
概括
一种新的绿色化学方法使用共振雷利散射检测帕金森病的Rasagiline (RSG). 这种敏感的测定量化了药物配方中的RSG,确保了治疗质量.
科学领域:
- 分析化学 分析化学
- 绿色化学 绿色化学
- 药品分析 药品分析
背景情况:
- 拉萨吉林 (RSG) 是帕金森病的关键单胺氧化酶抑制剂,向多巴胺水平.
- 准确量化RSG对于治疗疗效和患者安全至关重要.
研究的目的:
- 开发一种敏感,可行的,绿色的分析方法来确定拉萨吉林 (RSG).
- 为了验证药品分析和内容均性评估的方法.
主要方法:
- 使用基于共振雷利散射 (RRS) 的单,绿色化学兼容的方法.
- 在酸性环境中利用了分子大小依赖的RRS现象,来自Erythrosine-RSG复合体的形成.
- 根据国际协调理事会 (ICH) 的指导方针,优化和验证了该方法.
主要成果:
- 该方法表明RSG的线性反应在501400 ng/mL范围内.
- 达到低检测极限 (15.18 ng/mL) 和量化极限 (46 ng/mL),表明高灵敏度.
- 成功地应用了方法来量化RSG的药物剂量形式,并评估内容的均性.
结论:
- 开发的基于RRS的方法为RSG分析提供了灵敏,快速和环保的方法.
- 该方法的验证和成功应用证实了其对药品质量控制的可靠性.
- 这项工作突出了RRS技术在药物分析和内容统一性测试中的潜力.
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