具有正常素活性和水平的脏柔合细胞瘤:一个病例报告
Yoko Kohno1,2, Satoshi Nitta3, Kozaburo Tanuma1
1Department of Urology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Journal of medical case reports
|July 27, 2025
概括
这项案例研究突出显示了一种罕见的柔合细胞瘤,表现为高血压,但正常的蛋白活性和. 在患有质和高血压的患者中,早期的激素检测对诊断至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 脏副球细胞瘤是罕见的,良性瘤.
- 这些瘤通常会导致二次性高阿尔多斯特症,这是由于氨酸的产生,导致高血压,氨酸活性升高和低血.
研究的目的:
- 报告一个独特的柔合球体细胞瘤病例.
- 强调考虑这种诊断的重要性,即使有非典型的荷尔蒙发现.
主要方法:
- 一名39岁的男性患有失控的高血压,出现质.
- 图像检测显示了右皮质质量和双侧上腺质量.
- 荷尔蒙测试显示血雷宁活性正常,但血阿尔多素度升高.
主要成果:
- 患者接受了部分瘤切除术,以获得质.
- 手术后,高血压和高阿尔多斯特隆症得到解决.
- 组织病理学证实了一种并细胞瘤.
结论:
- 在患有脏质量和高血压的患者中,不论血内的活性如何,都应考虑结合细胞瘤.
- 对于患有无法解释的高血压和质的患者,建议进行激素检测.
相关概念视频
Renal Corpuscle
3.3K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
3.3K
Renal Tubule and Collecting Duct
1.5K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
1.5K
Hormonal Regulation
33.7K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.7K
Antihypertensive Drugs: Potassium-Sparing Diuretics
773
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
773
Renal Regulation of Acid-Base Balance
714
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
714
Renal Drug Excretion: Tubular Secretion
363
Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
363


