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产前饥饿暴露和晚年功能性大脑网络连接:一项纵向研究

Amber Boots¹, Jessica S Damoiseaux², Youjin Jung³

¹Amsterdam UMC Location University of Amsterdam, Department of Epidemiology and Data Science, Meibergdreef 9, Amsterdam, the Netherlands; Aging and Later Life, Amsterdam Public Health, Amsterdam, the Netherlands; Amsterdam Reproduction and Development, Amsterdam, the Netherlands.

|July 27, 2025

概括

产前饥饿暴露并没有改变大脑网络连接的变化到老年成人. 纵向分析显示,暴露和未暴露组之间的静止状态功能连接性 (RSFC) 衰老没有差异.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
老年学是指老年学的学科.

背景情况:

产前环境因素,如饥荒暴露,可以对大脑发育和成年后的功能产生持久的影响.
之前的研究在荷兰饥荒队列中发现了关键大脑网络在68岁休息状态功能连接 (RSFC) 的性别特异性差异.

研究的目的:

调查68至74岁之间默认模式网络 (DMN),突出网络 (SN) 和中央执行网络 (CEN) 的RSFC的纵向变化.
为了比较暴露和未暴露于早孕时期饥荒的个体之间的这些变化.

主要方法:

用完整信息最大概率估计的潜在变化得分建模来分析纵向RSFC数据.
DMN,SN和CEN的网络内和网络之间的连接性在115名68岁和74岁的80岁个人中进行了评估.
这项研究比较了在怀孕早期暴露于饥荒的个体与未暴露的个体.

主要成果:

在基线RSFC (截断) 或DMN,SN和CEN的网络内连接的变化速度 (斜率) 中没有发现显著的群体差异.
网络间连接的模型不合适,阻止了群组比较.
在两组中,DMN连接性随着时间的推移而增加,DMN和SN之间的负功能连接性也增加了.

结论:

与未暴露的个体相比,产前饥饿暴露并没有导致与衰老相关的大脑网络连接的更明显的变化.
这项研究没有提供证据证明RSFC在早孕饥荒暴露后的加速大脑衰老模式.
大脑网络连接的纵向变化在老年成人中看起来很强大,并且在这个群体中没有受到早期饥荒暴露的影响.

关键词:

衰老的衰老衰老的衰老功能连接性的功能连接性.产前营养不良产前营养不良休息状态的休息状态.功能磁力共振成像 (fMRI) 是一种

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