卵巢激发用Delta是安全和有效的:来自RITA随机,双盲,安慰剂对照试验的结果
Michael D Scheiber1, Kevin J Doody2, Eric D Foster3
1Institute for Reproductive Health, Cincinnati, Ohio.
Fertility and sterility
|July 27, 2025
概括
福利特罗平三角蛋白在卵巢刺激中表现出卓越的疗效,用于体外受精/细胞内精子注射,导致18-42岁妇女持续妊娠和活产率更高.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 药理学 药理学是指药理学的学科.
背景情况:
- 试管婴儿 (IVF) 和细胞内精子注射 (ICSI) 是关键的辅助生殖技术.
- 卵巢刺激是IVF/ICSI周期的关键第一步,旨在最大限度地提高所取卵子的数量.
研究的目的:
- 评估在接受试管婴儿/ICSI的女性卵巢刺激中利三角蛋白的疗效和安全性.
- 为了在两个年龄组中比较叶芽素三角蛋白与安慰剂:18-34岁和35-42岁.
主要方法:
- 两项随机,双盲,安慰剂控制的多中心试验 (RITA-1和RITA-2) 涉及1,165名患者.
- 患者在淋巴激素释放激素对抗剂协议中接受了叶叶三角形或安慰剂,叶叶三角形的固定起始剂量取决于年龄.
- 主要结局是新鲜和冷保存周期后累积持续怀孕率.
主要成果:
- 与安慰剂相比,在两个年龄组中,follitropin delta显著增加了累积持续怀孕率 (64.0%与0%对18-34岁;43.9%与0%对35-42岁).
- 累积活产率同样高于叶叶三角素 (62.5%为18-34岁;42.4%为35-42岁).
- 卵巢过度刺激综合征的发生率很低 (3.8%和2.4%在新生周期的各年龄组).
结论:
- 根据母亲的年龄给药时,利三角蛋白是IVF/ICSI患者卵巢刺激的有效和安全治疗方法.
- 这项研究证实,在实现怀孕和活产方面,利热三角蛋白比安慰剂优越.
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