美国人口中饮食炎症指数和子宫内膜异位症之间的关联:一个横截面研究
1Guangzhou University of Chinese Medicine, Guangzhou, China; Department of Chinese Medicine, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China.
通过饮食炎症指数 (DII) 测量较高的炎症饮食与子宫内膜异位症风险增加有关. 针对炎症的饮食改变可能有助于控制这种情况.
科学领域:
- 生殖健康 生殖健康
- 营养科学 营养科学
- 慢性疾病流行病学 慢性疾病流行病学
背景情况:
- 子宫内膜异位症是生殖年龄妇女普遍存在的炎症状况.
- 饮食炎症指数 (DII) 量化了与饮食相关的炎症.
- DII与子宫内膜异位症的关联尚未得到充分证实.
研究的目的:
- 调查饮食炎症指数 (DII) 和子宫内膜异位症之间的关系.
- 探索潜在的非线性趋势,并对这种关联进行影响的修改.
- 开发基于DII.II的子宫内膜异位症风险预测模型.
主要方法:
- 从2001-2006年NHANES中对4149名女性 (287名患有子宫内膜异位症) 的横截面分析.
- 后勤回归和受限立方线 (RCS) 评估了DII与子宫内膜异位症的关联.
- 为了风险预测而开发的 LASSO 回归和名图.
主要成果:
- 患有子宫内膜异位症的女性表现出更高的DII得分 (1.69对1.48,P=0.044).
- 增加的DII四分位数与更高的子宫内膜异位症几率相关 (Q4与Q1相比或1.40,P<0.001).
- 在老年女性,体重指数较高的女性和吸烟者中观察到更强的关联; nomogram AUC 66.6%.
结论:
- 较高的DII分数与子宫内膜异位症的几率增加有显著的关联.
- 旨在减少炎症的饮食干预措施显示出对子宫内膜异位症管理的希望.
- 对抗炎症饮食的进一步研究可能会提供新的治疗策略.
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