胆道伪瘤与肝缩相关
Albina Joldoshova1, Binny Khandakar1, Hwajeong Lee2
1Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Human pathology
|July 27, 2025
概括
广泛的管状扩散可以模仿胆管癌,特别是肝缩. 仔细审查临床,成像和组织学特征对于准确诊断这些罕见的胆道伪瘤至关重要.
科学领域:
- 肝胆病理学 肝胆病理学
- 手术病理学手术病理学
- 胃肠病学 胃肠病学
背景情况:
- 广泛的管状扩散可以呈现为伪瘤性病变,模仿分化良好的胆管癌.
- 这个实体在现有的医学文献中没有得到很好的描述.
研究的目的:
- 评估模仿胆管癌的反应性结状扩散的临床病理特征.
- 为了区分这些病变与实际的胆管癌.
主要方法:
- 追溯分析了四个模仿胆管癌的反应性管状扩散病例.
- 临床病理特征的详细研究,包括粗略检查,组织学和免疫组织化学.
- 从1995年到2024年,在两个主要的学术卫生机构确定了病例.
主要成果:
- 病例包括扩张和切除,有些人显示肝缩,门静脉血栓症和肝硬化.
- 在组织学上,病变显示出明显的管状增殖,但缺乏显著的细胞性异型和线性活动.
- 免疫组织化学检测显示野生类型的p53,并保留了p16和BAP1的表达.
结论:
- 与叶片缩相关的胆管伪瘤可以模仿胆管癌,无论是粗略的还是微观的.
- 准确的诊断需要意识到这种现象,并仔细整合临床,成像和微妙的组织学发现.
相关概念视频
Chronic Pancreatitis I: Introduction
162
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
162
Diseases of the Liver and Gallbladder
1.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.0K
Chronic Pancreatitis II: Collaborative Care
128
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
128
Gallbladder
924
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
924
Gastritis-II: Pathophysiology
556
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
556


