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纳米欧米和纳米医学针对微生物致癌:瘤微环境重新编程到临床翻译

Vincent Kawuribi¹, Yiyang Xie¹, Haiqing Xu²

¹School of Medical Imaging, Xuzhou Medical University, Xuzhou 221006, China.

Critical reviews in oncology/hematology

|July 27, 2025

概括

微生物感染通过炎症和免疫逃避驱动癌症. 纳米医学提供了新的策略,通过重新编程瘤微环境,并使得theranostics通过针对这些微生物相关的瘤.

科学领域:

在瘤学瘤学.
微生物学微生物学
纳米技术纳米技术
免疫学免疫学免疫学

背景情况:

微生物感染对人类癌症有着重大影响.
像Helicobacter pylori,HPV和HBV这样的病原体通过炎症,基因毒素和免疫逃避引起瘤发生.
瘤微环境 (TME) 在微生物致癌过程中至关重要.

研究的目的:

审查微生物致癌物及其机制.
探索针对微生物相关瘤的纳米启用策略.
讨论纳米医学在调节瘤免疫微环境 (TIME) 中的作用.

主要方法:

2010-2025年研究的文献综述.
对微生物致癌机制和TME变化的分析.
对纳米疗法,纳米粒子疫苗,纳米奥米克和神经系统的检查.

主要成果:

确定了关键的微生物参与者 (H. pylori,HPV,HBV,F. nucleatum,schistosomes) 和它们的致癌途径.
突出纳米疗法针对特定的微生物和纳米粒子疫苗.
详细介绍了纳米医学在重新编程免疫细胞 (TAM,树突细胞) 和克服免疫抑制方面的作用.
展示了用于综合成像和治疗的治疗系统.

结论:

纳米方法协同作用,抵消微生物致癌和重编程TME.
纳米医学在治疗微生物相关癌症方面具有显著的临床转化潜力.
未来的研究应该专注于优化这些纳米战略,以提高治疗效果.

关键词:

临床翻译临床翻译免疫调节是一种免疫调节.微生物致癌的发生.纳米医学是一种纳米医学.瘤微环境重编程

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