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Updated: Sep 13, 2025

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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使用机器学习指导和评估阿司匹林用于偏好的COX-2抑制的分子修饰

Qi Yang1, Guiyuan Pang1, Meiyu Huang1

  • 1Faculty of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR China; Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, Nanning 530200, PR China.

Journal of pharmaceutical sciences
|July 27, 2025
PubMed
概括

研究人员修改了阿司匹林以选择性抑制COX-2酶,减少胃肠道副作用. 这种计算机辅助设计方法可以增强治疗效果,同时最大限度地减少不良反应,使NSAID开发更安全.

关键词:
亚司匹林是一种阿司匹林.循环氧化基因酶 (Cyclooxygenase) 是一种机器学习 机器学习分子修饰是一种分子修饰.

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