了解难以治疗的牛皮关节炎:来自葡萄牙风湿病登记处的数据
Catarina Abreu1, Vanessa Fraga1, Sara Dias Rodrigues2
1Rheumatology Department, Hospital Garcia de Orta, Unidade Local de Saúde Almada-Seixal, Avenida Torrado da Silva, 2805-267 Almada, Portugal.
Joint bone spine
|July 27, 2025
概括
难以治疗的牛皮关节炎 (D2T PsA) 影响0.9%-3.7%的患者. 预测因素包括多关节性疾病和较高的基线疾病活性,表明需要在牛皮关节炎管理中进行早期干预.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 牛皮关节炎 (PsA) 是一种慢性炎症性疾病.
- 识别难以治疗的 (D2T) PsA对于优化患者的治疗结果至关重要.
- 目前对D2T PsA患病率和预测因素的理解需要进一步调查.
研究的目的:
- 估计患有难以治疗的牛皮关节炎 (D2T PsA) 的患者比例.
- 确定与D2T PsA相关的临床和人口预测因素.
- 为临床实践和未来的研究方向提供信息,以管理具有挑战性的PsA病例.
主要方法:
- 一个多中心的观察后期研究,利用来自葡萄牙风湿病登记处 (Reuma.pt) 的数据.
- 根据治疗失败 (≥2或≥3 b/ts不同MOA的DMARDs) 和活跃/进展性疾病迹象,用于分类D2T PsA的两个不同的定义.
- 进行了统计分析,以确定相关的预测因素.
主要成果:
- 该研究包括1873名患者,根据两个定义,D2T PsA比例为3.7%和0.9%.
- D2T PsA与发病/诊断年龄较小,多关节性表型,抑郁症,肠炎和较低的BMI显著相关.
- 患有D2T PsA的患者表现出更高的基线疼痛/胀关节数量和DAPSA得分,以及更高的治疗中止率.
结论:
- D2T PsA的患病率在0.9%至3.7%之间.
- D2T PsA的主要预测因素包括多关节性疾病,更高的基线胀关节数量,以及初始b/tsDMARDs的更长的治疗持续时间.
- 在一线生物/向合成DMARDs启动之前,D2T PsA患者的疾病活性较大,并且治疗中断率较高.
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