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对草甘和轮对塞尔托利细胞增殖的影响的分析

Cecilia Lucia Centola¹, Marina Ercilia Dasso¹, Agostina Gorga¹

¹Centro de Investigaciones Endocrinológicas, "Dr.Bergada César Bergadá", CONICET-FEI-División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Argentina.

Environmental toxicology and pharmacology

|July 27, 2025

概括

草药Roundup (R) 没有影响大鼠的塞尔托利细胞增殖或精子生产. 在这项研究中,早期接触Roundup并没有改变生殖功能.

科学领域:

生殖毒理学生殖毒理学
环境健康环境健康
内分泌学在内分泌学.

背景情况:

塞尔托利细胞 (SC) 对于男性生殖功能和精子生产至关重要.
含有草甘 (G) 的Roundup (R) 已被调查是否可能对男性生育能力产生不良影响.
在早期发育期间的SC增殖对于建立成人精子生产能力至关重要.

研究的目的:

为了研究草甘 (G) 和轮 (R) 对塞尔托利细胞 (SC) 增殖的影响.
评估早期暴露于R对成年大鼠每日精子生产 (DSP) 的影响.

主要方法:

实验室研究使用大鼠塞尔托利细胞培养物来测量BrdU的结合.
在体内研究中,在最大的SC增殖期 (PND 3-7) 中,每天给大鼠服用R.
评估每日精子产量在成年大鼠治疗R从PND 3-14.

主要成果:

在体外,R降低了FSH刺激的BrdU在SC培养中的融入,而单独的G没有影响.
在体内,从PND 3-7进行R治疗并没有改变SC增殖 (BrdU结合).
成年大鼠用PND 3-14的R治疗的DSP保持不变.

结论:

在未成熟的老鼠中,早期接触Roundup (R) 似乎不会影响塞尔托利细胞的增殖.
在早期发育期间使用Roundup (R) 治疗不会改变成年雄性大鼠的每日精子产量.

关键词:

草甘是一种天然的草甘.核武器的扩散综合总结综合总结综合总结塞尔托利细胞是Sertoli细胞.测试 (Testis) 是一个测试.

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