低频超声波触发药物从低强度的 perfluorocarbon 滴中释放出来的药物
Sofia Sirolli1, Faraz Amini Boroujeni2, Lorena Guachi-Guachi1
1The BioRobotics Institute, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy; Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy.
Ultrasonics
|July 27, 2025
概括
稳定的 perfluorocarbon 滴提供超声波触发的药物输送. 这项研究表明,低频超声波可以在安全的压力下激活这些液滴,从而使药物在潜在的体内应用中有效释放.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 由于可调节的特性和可控的货物释放, perfluorocarbon 液滴对超声波触发的药物输送有希望.
- 目前的稳定滴滴配方需要高超声压 (>1 MPa),这引起了体内使用的安全问题.
- 在滴滴稳定性和安全激活值之间取得平衡仍然是一个关键挑战.
研究的目的:
- 为了研究稳定的表面活性剂外的 perfluoropentane 滴对低强度脉冲超声波的反应.
- 为了证明在低超声压 (100 kPa) 和低频率 (38 kHz) 下有效释放药物.
- 优化超声波刺激参数,以有效地输送药物,同时遵守安全指南.
主要方法:
- 使用了稳定的表面活性剂外的 perfluoropentane 滴.
- 应用低强度脉冲超声波在38kHz.
- 系统地改变了超声波参数:压力,脉冲重复频率和工作周期.
- 采用高速摄像机和超声波成像来分析滴滴的行为.
主要成果:
- 在低至100kPa的压力下使用38kHz超声波触发了显著的药物释放.
- 在各种低频超声波刺激参数下,特征性滴滴行为.
- 优化了一种在安全指南范围内有效释放药物的协议.
结论:
- 稳定的 perfluoropentane 滴滴可以在安全的压力水平下通过低频超声波激活.
- 这种方法促进了有效的药物释放,为体内翻译铺平了道路.
- 进一步优化超声波参数可以提高药物输送效率.
更多相关视频
相关概念视频
Atomic Fluorescence Spectroscopy
Atomic fluorescence spectroscopy (AFS) is an analytical technique that involves the electronic transitions of atoms in a flame, furnace, or plasma being excited by electromagnetic (EM) radiation. When these atoms absorb energy, they become excited and subsequently release energy as they return to their original state. This emitted light, or "fluorescence," is observed at a right angle to the incident beam. Both absorption and emission processes transpire at distinct wavelengths, which are...
Drug Delivery: Miscellaneous Routes
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed I
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...


