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Updated: Sep 13, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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基于KEAP1的PROTAC作为新兴治疗模式的进展:结构基础和进展

Jing Chen1, Disheng Feng2, Rui Zhu1

  • 1Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.

Redox biology
|July 27, 2025
PubMed
概括

凯尔克类ECH相关蛋白1 (KEAP1) 是细胞氧化还原平衡的关键调节者. 新的蛋白质溶解向金马 (PROTACs) 利用KEAP1降解与疾病相关的蛋白质,提供了一个有前途的治疗途径.

关键词:
在 CUL3 中,我们可以使用 CUL3 .抑制剂是一种抑制剂.这就是 KEAP1 的特点.这就是NRF2的NRF2.这就是 PROTACs.在Ubiquitination中使用.

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