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Updated: Sep 13, 2025

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在高突破条件下保持时间分布的机械建模,用于连续的蛋白质A亲和度捕获

Wu-Wei Chen1, Yan-Na Sun1, Yu-Cheng Chen1

  • 1Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang Key Laboratory of Smart Biomaterials, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.

Journal of chromatography. A
|July 27, 2025
PubMed
概括

保留时间分布 (ReTD) 对于连续色谱中的材料可追溯性至关重要. 这项研究开发并验证了蛋白A亲和色谱的新型ReTD模型,改善了对材料流的理解,并使实时产品释放成为可能.

关键词:
连续的过程过程.建模建模模型是什么蛋白质A亲和性染色学 蛋白质A亲和性染色学居住时间的分布.保留时间的分布.

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Physiological models with protein binding in pharmacokinetics offer a sophisticated approach to understanding drug disposition. These models consider drug-protein interactions, enabling them to effectively predict drug concentrations in different organs and tissues. This precision aids in accurate drug dosing, providing a significant advantage over conventional models. A key process within these models is equilibration, which ensures that drug concentrations achieve a steady state within the...
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