在土壤中共同存在的细菌群体在有机肥化下作为抗生素耐药性决定因素的聚集中心
Ya-Lan Hong1, Wei-Ming Xi1, Ya-Ting Wang1
1Jiangsu Key Laboratory for Organic Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, 210095, China.
Journal of environmental management
|July 27, 2025
概括
有机肥在土壤中传播抗生素耐药性基因 (ARG),但大多数迅速降解. 高地条件降低了ARG的持久性,与洪水不同,这有助于基因转移.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 农业科学 农业科学
背景情况:
- 抗生素耐药性决定因素 (ARDs) 通过环境传播传播,威胁人类健康.
- 农业有机肥料是土壤生态系统中ARDs的重要来源.
- 了解ARD的命运和水资源管理的影响对于减轻耐药传播至关重要.
研究的目的:
- 研究有机肥后在土壤中ARDs的衰减和持久性.
- 评估不同水利管理制度 (高原,连续洪水,间歇性洪水) 对ARD命运的影响.
- 探索土壤细菌群落在ARD传播中的作用.
主要方法:
- 在不同的水资源管理下,对土壤施加有机肥的实地研究.
- 随着时间的推移,ARDs和细菌宿主的量化.
- 分析ARD成分和土壤细菌社区结构.
主要成果:
- 大多数引入的ARD显示显著减弱 (19-50天半衰期),与宿主细菌衰减有关.
- 特定的ARDs (例如, aph(3') -IIIa,tetO) 在所有治疗中都持续存在.
- 高地条件加速了ARD减弱;洪水延长了生存时间,促进了水平基因转移.
- 土壤细菌群落作为ARD传播的枢纽,对环境变化表现出敏感性.
结论:
- 土壤细菌群体是有机肥料中ARDs的主要传播者.
- 水资源管理显著影响ARD的持久性和转移.
- 准土壤微生物社区中心可以减轻环境抗生素耐药性的传播.
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