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通过调节线粒体裂变和氧化应激,S100A9抑制可以改善HFpEF

Moran Wang1, Bowen Ren2, Xiaofan Wu2

  • 1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, China; Key Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, China.

International immunopharmacology
|July 27, 2025
PubMed
概括

保存喷射分数 (HFpEF) 的心力衰竭涉及S100A9驱动线粒体问题. 在HFpEF模型中,抑制S100A9及其通路 (SPI1/PDK4) 改善心脏功能并减少氧化应激.

关键词:
心力衰竭与保存的喷射分数的心脏衰竭线粒体裂变的线粒体裂变氧化应激是一种氧化应激.在PDK4中使用PDK4.在S100A9A9中使用.

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