低音神经刺激器用于13岁以下的唐氏综合征儿童的阻塞性睡眠呼吸暂停
Minjee Kim1, Lucy J Xu1, E'Ching Shih1
1Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
International journal of pediatric otorhinolaryngology
|July 27, 2025
概括
低分泌神经刺激 (HGNS) 植入是安全有效的治疗严重阻塞性睡眠呼吸暂停 (OSA) 在13岁以下的唐氏综合征 (DS) 的儿童. 这种程序显示了与老年患者相比的有希望的结果,提供了一个新的治疗选择.
科学领域:
- 儿科耳鼻喉科 儿科耳鼻喉科
- 睡眠医学 睡眠医学
- 遗传学 遗传学 是一个
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 在患有唐氏综合征 (DS) 的儿童中很常见.
- 腺切除术是主要的治疗方法,但通常无法在这个人群中解决OSA.
- 低音神经刺激 (HGNS) 是FDA批准的13岁以上的DS患者,但对于患有严重OSA的年轻儿童存在需要.
研究的目的:
- 评估HGNS植入在13岁以下患有唐氏综合征和严重OSA的儿童中的安全性和有效性.
- 在这个儿科队列中评估术后并发症和治疗反应.
主要方法:
- 在两个学术机构进行的回顾性队列研究.
- 包括29名13岁以下的儿童患有DS和严重的OSA,他们接受了HGNS植入.
- 记录了患者的人口统计,手术并发症和多睡眠数据 (手术前后的呼吸暂停-呼吸暂停指数).
主要成果:
- 所有29名儿童 (年龄在4-12岁) 安全地植入了植入物,没有严重的不良事件;一个轻微的伤口并发症得到解决.
- 手术前的中位数呼吸暂停-呼吸暂停指数 (OAHI) 为18.4,在术后显著下降至3.9 (p < 0.001).
- 在6个月后,95.2%的患者实现了OAHI≥50%的减少.
结论:
- 植入HGNS是一种安全的程序,适用于4至13岁的患有唐氏综合征和严重OSA的儿童.
- 最初的疗效结果表明,结果与13岁以上的患者观察到的结果相似.
- 这项研究支持HGNS作为患有DS的年幼儿童严重OSA的可行治疗选择.
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