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Updated: Sep 13, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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SUGP1损失驱动SF3B1热点突变在癌症中错误发生

Peiqi Xing1, Pedro Bak-Gordon2, Jindou Xie3

  • 1National Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.

Cell reports
|July 27, 2025
PubMed
概括

在SF3B1拼接因子的突变导致癌症错误拼接. 失去了SUGP1蛋白完全模仿这些缺陷,而失去了水瓶座 (AQR) 有间接的影响,突出了SUGP1的关键作用.

关键词:
一个 AQR AQR.科普:分子生物学 分子生物学DDX42 DDX42 在线播放DDX46 DDX46 在线播放DHX15 DHX15 的时间.这就是SETX.在SF3B1中.在 SUGP1 中,癌症 癌症 癌症 癌症 癌症突变是发生在突变中的突变.拼接 拼接 拼接 拼接

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