相关实验视频
Updated: Sep 13, 2025
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
21.2K
甲状腺瘤和状腺癌的比较,没有最初的远程转移
Pierre Puygrenier1,2, Gabrielle Deniziaut2,3, Sebastien Gaujoux1,2,4
1Department of General, Visceral, and Endocrine Surgery, Pitié-Salpêtrière Hospital AP-HP, Paris, France.
World journal of surgery
|July 27, 2025
概括
细胞性甲状腺癌 (OTC) 的复发率与卵泡性甲状腺癌 (FTC) 的复发率相似. 这表明,对OTC来说,一种不那么密集的管理方法可能是合适的,这挑战了对其不良预后的传统观点.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 病理学 病理学 病理学
背景情况:
- 瘤细胞性甲状腺癌 (OTC) 是毛囊性甲状腺癌 (FTC) 的一个亚型,在历史上被认为预后不佳.
- 关于OTC临床病理特征和结果的数据有限而异质.
- 本研究旨在通过比较OTC和FTC来澄清OTC的预后.
研究的目的:
- 研究瘤性甲状腺癌 (OTC) 的临床病理学特征.
- 为了比较OTC与状甲状腺癌 (FTC) 的预后.
- 评估OTC和FTC患者之间的复发率和生存结果.
主要方法:
- 在接受OTC或FTC全甲状腺切除术的患者中进行了一项回顾性比较研究.
- 收集的数据包括人口统计,临床病理学特征,并发症和复发率.
- 用单变量和多变量回归分析进行比较.
主要成果:
- 该研究包括347名患者 (123名OTC,224名FTC),OTC患者年龄大得多.
- 两组之间在其他人口统计学,临床或病理学特征方面没有发现显著差异.
- 复发率相似 (OTC为5.7%,FTC为4.9%),无复发生存率没有差异 (p=0.47).
结论:
- 囊性甲状腺癌 (OTC) 的复发率与囊性甲状腺癌 (FTC) 的复发率相当.
- 组织学类型的OTC似乎不是复发的独立风险因素.
- 对于OTC,可以考虑采用不那么密集,逐步的治疗管理,挑战其传统的不良预后.
相关概念视频
01:23The Thyroid Gland
4.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.4K
02:30Metastasis
5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K
00:59The Parathyroid Glands
2.6K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.6K
02:07Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K