在可能满足发育协调障碍标准的儿童的神经诊断
Martinica Garofalo1,2, Fleur Vansenne2,3, Jessika F van Hoorn4
1Department of Pediatric Neurology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
初步的神经学评估对于诊断儿童发育协调障碍 (DCD) 的预测很差. 许多具有替代诊断的病例都有潜在的遗传原因,这表明需要进行神经遗传测试.
科学领域:
- 儿科神经学 儿科神经学
- 发育儿科 发育儿科
- 临床遗传学 临床遗传学
背景情况:
- 发育协调障碍 (DCD) 影响儿童的运动技能.
- 准确的诊断对于及时干预至关重要.
- 从初步评估中预测DCD诊断仍然具有挑战性.
研究的目的:
- 评估DCD诊断初始神经现象类型评估的预测准确性.
- 为了比较患有DCD的儿童的临床和诊断参数与替代诊断.
主要方法:
- 对50名被评估为DCD的儿童进行了回顾性队列研究.
- 来自儿童神经病理门诊的医疗记录的分析.
- 计算DCD和替代诊断的预测值.
主要成果:
- 62%的儿童被诊断出患有DCD,38%的儿童被诊断出另一个诊断.
- 对DCD的积极预测值为52%;对于替代诊断,21%.
- 没有发现群体之间的统计学意义上的区分参数.
结论:
- 最初的神经现象类型评估不足以预测DCD诊断结果.
- 在替代诊断中遗传病因的高流行率需要进一步调查.
- 建议对儿童进行额外的神经遗传评估,以评估DCD.
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