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二醇对慢性鼻炎的影响,随机临床试验

M Popko-Zagor¹, P Jandziak², J Sierdziński³

¹Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical University of Warsaw, Warsaw, Poland.

|July 27, 2025

概括

将calcifediol添加到用budesonide的盐水洗鼻液中,显著改善了慢性鼻炎 (CRS) 患者的结果,使许多人能够停止使用鼻类固醇.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
内分泌学在内分泌学.
药理学药理学是指药理学的学科.

背景情况:

慢性鼻炎 (CRS) 是一个普遍的疾病.
鼻内维生素D在CRS治疗中显示出有前途.
二醇是维生素D的一种形式.

研究的目的:

为了评估加二醇在CRS患者用布德索尼德注盐酸鼻腔灌的疗效.
在一项随机临床试验中,将calcifediol治疗与安慰剂进行比较.

主要方法:

113名成年CRS患者被随机分配到calcifediol或安慰剂组.
参与者在21天内每天两次灌鼻腔.
测量结果包括SNOT-22分数,Lund-Kennedy (L-K) 分级和鼻类固醇停止.

主要成果:

在calcifediol组中观察到SNOT-22和L-K得分的显著改善.
卡尔西费迪奥尔组的显著比例的患者停止了鼻类固醇的使用.
血清25(OH) D度在calcifediol组显著增加.

结论:

二醇与盐水和布德索尼德相结合,为CRS提供了显著的临床益处.
这种治疗方法比单独的盐水和布德索尼德具有优势.
二醇代表了慢性鼻炎管理的有前途的治疗选择.

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