"25.2%博斯卡利德+12.8%皮拉克洛斯特罗宾"杀菌剂的细胞毒性作用
1Department of Pathology Laboratory Techniques, Şuhut Vocational School of Health Services, A fyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
Journal of applied toxicology : JAT
|July 27, 2025
概括
这项研究评估了博斯卡利德和皮拉克洛斯特罗宾杀菌剂对Triticum生长和MDBK细胞的毒性影响. 虽然推剂量显示出有限的细胞遗传影响,但较高度会抑制生长并表现出细胞毒性.
科学领域:
- 农业科学 农业科学
- 环境毒理学环境毒理学
- 植物科学 植物科学
背景情况:
- 杀虫剂,包括杀菌剂,可以对非目标生物产生有毒作用.
- 博斯卡利德和皮拉克洛斯特罗宾是农业杀菌剂中常见的活性成分.
- 了解这些化合物的植物毒性和细胞毒性对于风险评估至关重要.
研究的目的:
- 为了评估博斯卡利德/皮拉克洛斯特罗宾杀菌剂对Triticum的增长抑制作用.
- 评估杀真菌剂对根的线粒活性的影响.
- 为了确定杀菌剂对MDBK细胞的细胞毒性作用.
主要方法:
- 进行了Triticum根和茎生长抑制试验.
- 确定了根和茎长度抑制的EC50值.
- 在MDBK细胞上进行了根线性指数分析和MTT测定.
主要成果:
- 杀菌剂在Triticum中表现出根长度为2500 ppm和茎长度为1250 ppm的EC50值.
- 所有测试度都对线粒活性产生了负面影响,10,000 ppm显示了最显著的减少.
- 在所有度中观察到对MDBK细胞的细胞毒性作用,尽管一些较低的剂量没有显示出统计学意义.
结论:
- 这种杀菌剂在较高度下显示出植物毒性和细胞毒性潜力.
- 推的农业应用剂量 (大约500 ppm) 似乎具有有限的细胞遗传效应.
- 需要进一步研究这种杀菌剂对环境和细胞的影响.
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