肠道微生物群塑造癌症免疫疗法反应
Wanting Lei1,2, Kexun Zhou3, Ye Lei4
1Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
NPJ biofilms and microbiomes
|July 27, 2025
概括
肠道微生物群通过改变免疫活动和瘤微环境,影响癌症免疫治疗的成功. 基于微生物群的策略,如便微生物群移植 (FMT) 和益生菌,显示出改善癌症治疗的潜力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 肠道微生物群在宿主免疫和新陈代谢中起着至关重要的作用.
- 癌症免疫疗法,包括免疫检查点抑制剂 (ICI) 和采用细胞疗法 (ACT),已经彻底改变了癌症治疗.
- 新出现的证据将肠道微生物组成与接受免疫治疗的癌症患者的临床结果联系起来.
研究的目的:
- 审查肠道微生物群对癌症免疫疗法疗效的影响.
- 总结基于微生物群的干预措施的临床前和临床发现.
- 讨论准确免疫疗法利用微生物组的未来方向.
主要方法:
- 对临床前和临床研究进行全面的文献搜索.
- 分析肠道微生物群影响免疫疗法的机制 (免疫调节,TME重塑,代谢物产生).
- 评估针对肠道微生物群的治疗策略 (FMT,益生菌,饮食).
主要成果:
- 肠道微生物群的组成与患者对ICI和ACT的反应有显著的相关性.
- 微生物群衍生代谢物可以增强抗瘤免疫力,降低治疗毒性.
- 像FMT和益生菌这样的干预措施在调节肠道微生物群方面表现有希望,以改善免疫治疗结果并减少与免疫相关的不良事件 (irAEs).
结论:
- 肠道微生物群是癌症免疫疗法疗效的关键决定因素.
- 准肠道微生物组为增强当前癌症治疗提供了一个有希望的途径.
- 基于微生物群的个性化策略有可能优化精密免疫疗法.
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