儿科胃肠道基底球菌病:描述性的双中心回顾性研究
Nabil S Dhayhi1, Alanoud Zaid Aljarbou2, Abdulaziz H Alhazmi3
1Department of Pediatric Infectious Diseases, Jazan Health Cluster, King Fahd Central Hospital, Jazan, Saudi Arabia.
Scientific reports
|July 27, 2025
概括
儿科胃肠道基球菌病 (GIB) 是一种罕见的真菌感染,可以有效地用利康纳单疗法治疗,特别是当早期诊断时. 肝脏的参与可能会使儿童的结果复杂化.
科学领域:
- 菌类学 菌类学是指菌类学.
- 儿童传染病 儿童传染病
- 胃肠病学 胃肠病学
背景情况:
- 儿科胃肠道基球菌病 (GIB) 是一种罕见的由 Basidiobolus ranarum 引起的真菌感染.
- 它主要影响热带和亚热带地区的儿童,通常与农业环境有关.
研究的目的:
- 提供儿科GIB的临床,诊断和治疗见解.
- 分析来自沙特阿拉伯的双中心回顾案例系列.
主要方法:
- 对沙特阿拉伯两家三级医院的42例儿科GIB病例进行了回顾性分析.
- 收集的数据包括人口统计,临床表现,诊断 (组织病理学,培养),治疗和结果.
- 诊断依赖于临床怀疑,流行病学和组织病理学,微生物学证据有限.
主要成果:
- 大多数病例 (64%) 是男性和幼儿 (76% ≤6岁),主要来自贾赞省.
- 肠道是受影响最多的器官 (90.47%),其次是肝脏 (29%).
- 伏利康纳单一治疗显示高疗效 (83%),尽管33%需要手术;发生复发和持续性感染,特别是肝脏参与. 没有观察到死亡率.
结论:
- 早期识别和及时的抗真菌疗法,特别是沃里可纳,对于有利的儿科GIB结果至关重要.
- 肝脏受影响是一个挑战,可能导致并发症和复发.
- 需要进一步的研究来优化儿科GIB的诊断和治疗策略.
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