在日本儿童中,Streptococcus mutans携带编码细胞表面蛋白Cnm的cnm基因的流行率
Yuto Suehiro1, Makoto Okuda2, Masatoshi Otsugu2
1Department of Pediatric Dentistry, Graduate School of Dentistry, The University of Osaka, 1-8 Yamada-Oka, Suita, Osaka, 565-0871, Japan. suehiro.yuto.dent@osaka-u.ac.jp.
Scientific reports
|July 27, 2025
概括
来自Streptococcus mutans的原结合蛋白 (Cnm) 可能会增加儿童腔风险. 阳性Cnm菌株与日本儿童的较高腔得分和原结合能力有关.
科学领域:
- 口腔微生物学 口腔微生物学
- 传染病 传染病 传染病
- 儿科牙科 儿科牙科
背景情况:
- 牙虫是一种常见的感染,由Streptococcus mutans引起.
- 突变性菌株产生一种与心血管疾病相关的原结合蛋白 (Cnm).
- 有限的数据存在于Cnm阳性S. mutans在日本儿童中的流行和.
研究的目的:
- 调查日本儿童中S. mutans和Cnm阳性菌株的流行情况.
- 评估Cnm存在,原结合能力和虫经验之间的关系.
- 为了确定Cnm阳性S. mutans是否是增加虫易感性的风险因素.
主要方法:
- 在日本大学医院调查了490名儿童.
- 隔离了S.mutans并检测到了cnm基因.
- 计算病经验 (dmft/DMFT) 和评估的原结合能力.
主要成果:
- 在36.8%的儿童中发现了S. mutans;10.1%的儿童携带Cnm阳性菌株.
- 患有Cnm阳性的S.突变菌的儿童的dmft/DMFT得分明显更高.
- 在Cnm阳性S. mutans的原结合能力和dmft/DMFT分数之间存在正相关性.
结论:
- 通过原介导的粘附在牙上,Cnm可能会促进的进展.
- 具有Cnm阳性的S. mutans存在是儿童脏病的潜在危险因素.
- 需要进一步的研究来了解Cnm在全身性疾病联系中的作用.
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