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Updated: Sep 13, 2025

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通过CASTOR1-GATOR2复合体进行mTORC1调节的结构基础

Rachel M Jansen1,2, Clément Maghe1,2, Karla Tapia1

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.

Nature structural & molecular biology
|July 27, 2025
PubMed
概括

这项研究揭示了素传感器CASTOR1如何与GATOR2复合体相互作用,以调节mTORC1的激活. 这种相互作用对于控制细胞代谢以响应营养的可用性至关重要.

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