在精神病中,在皮层和脊柱水平上改变了自我产生的感觉的处理
Paula C Salamone1,2, Adam Enmalm1,2, Reinoud Kaldewaij1,2
1Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, 58185, Linköping, Sweden.
Molecular psychiatry
|July 27, 2025
概括
患有精神病的患者难以区分自我产生的感觉,表现出处理触摸和从脊髓到大脑的身体内部信号 (内接收) 的障碍.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 感官处理 感官处理
背景情况:
- 精神病常常涉及到自我意识的改变和错误的感觉归因.
- 这些症状背后的基本身体自我处理障碍尚未得到充分理解.
- 身体幻觉和误解在精神疾病中很常见.
研究的目的:
- 研究精神病中自我唤起的感觉 (触摸,感知) 的处理.
- 使用多模式,多方法方法来检查神经和行为反应.
- 在患有精神疾病的患者中确定与自身相关的身体知觉中的特定障碍.
主要方法:
- 与70名参与者进行的病例控制研究 (35名精神病患者,35名对照).
- 采用功能性MRI,唤起潜力,以及行为/心理物理测试.
- 评估对自我和其他产生的触摸和心跳信号的反应.
主要成果:
- 患者在自我触摸时表现出右上旋激活的增加.
- 在脊髓层面和行为上受损的触觉自我-其他区别.
- 皮质内感应反应减弱,准确性降低,对心跳信号的敏感性降低.
结论:
- 精神病障碍的特点是普遍的感官和自我相关的处理障碍.
- 自我与外部唤起的反应的差异化受损,即使在脊髓层面,也可能是精神病症状的基础.
- 这些发现突出了精神病中身体自我处理的根本性干扰.
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