在患有缺铁症的儿科脏移植患者中使用铁性碳酸
Diletta Domenica Torres1, Luigi Antonio Moscogiuri2, Giulia Fontò3
1Pediatric Nephrology and Dialysis Unit, "Giovanni XXIII" Hospital, Via Amendola 207, Bari, 70124, Italy.
Pediatric nephrology (Berlin, Germany)
|July 27, 2025
概括
铁性碳酸 (FCM) 有效地治疗儿童移植患者的缺铁性贫血. 这种静脉注射铁疗法改善了血红蛋白和铁水平,没有观察到任何不良影响.
科学领域:
- 儿科脏病学 儿科脏病学
- 移植医学 移植医学
- 血液学 血液学 血液学
背景情况:
- 贫血是儿科移植患者经常出现的并发症.
- 缺铁是移植后贫血的常见原因,通常对口服铁反应不佳.
- 在此群体中,静脉注射铁性碳酸糖 (FCM) 的安全性和有效性以前没有被确立.
研究的目的:
- 评价铁性碳酸盐糖 (FCM) 的安全性和有效性,对患有缺铁 (ID) 和/或缺铁性贫血 (IDA) 的儿科移植患者进行评估.
主要方法:
- 单中心,回顾性队列研究.
- 包括诊断为ID/IDA (KDIGO指南) 的儿科移植患者,他们在2016年12月至2022年11月期间接受了FCM.
- 在基线和12个月后的随访点评估血红蛋白,费里丁,转激素和 (TSat) 和酸盐水平.
主要成果:
- 15名ID患者 (10名IDA患者) 接受了FCM.
- 在6个月内观察到血红蛋白 (1.2-1.4 g/dL) 和费里水平的显著增加.
- 治疗后30天,转林和度有所改善.
- 没有发现酸盐水平显著下降或不良反应.
结论:
- 铁性碳酸 (FCM) 似乎是儿童脏移植接受者对ID/IDA的有效和耐受性良好治疗方法.
- 需要更大,更强大的试验来证实这些发现.
相关概念视频
Kidney Transplant I: Introduction
60
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
60
Renal Failure: Dose Adjustments
161
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
161
Kidney Transplant II: Surgical Procedure
76
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
76
Kidney Transplant III: Nursing Management
82
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
82
Bone Marrow Sampling and Transplants
502
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
502
Chronic Kidney Disease III: Interprofessional Care
80
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
80


