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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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与癌症相关的TP53同名突变诱导了p53异型p53/47的合成

Rhythm Sajwan1, Lixiao Wang1, Olivera Casar-Borota2

  • 1Department of Medical Biosciences, Umea University, Umea, Sweden.

British journal of cancer
|July 27, 2025
PubMed
概括

同义突变 (SMs) 可以通过改变RNA结构来驱动癌症. 在TP53中特定的SM诱导p47蛋白异型,模仿细胞应激反应并突出SMs.

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