食脂肪的来源影响肥胖小鼠的抗瘤免疫力
Britta Kunkemoeller1, Hannah Prendeville2, Claire McIntyre1
1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nature metabolism
|July 27, 2025
概括
饮食脂肪来源影响癌症免疫力. 来自动物脂肪的高脂肪饮食加速黑色素瘤的生长,而植物油则没有,揭示了影响抗瘤免疫细胞的特定脂质代谢物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 肥胖是众所周知的各种癌症的风险因素,可以抑制免疫系统对抗瘤的能力.
- 不同饮食脂肪来源对瘤生长和抗瘤免疫在肥胖背景下的具体影响仍然在很大程度上未被探索.
研究的目的:
- 调查不同饮食脂肪来源如何影响肥胖模型中的瘤进展和抗瘤免疫反应.
- 为了确定特定的食脂肪衍生代谢物,负责调节瘤微环境中的免疫细胞功能.
主要方法:
- 采用了一种合成黑色素瘤小鼠模型,食各种高脂肪饮食 (HFDs),包括油脂,牛脂,黄油,子油,棕油和橄油.
- 评估瘤生长,免疫细胞透 (天然杀手细胞和CD8T细胞),血代谢和细胞内代谢.
- 确定了特定的脂质中间体,如长链乙卡尼丁,与差异性免疫反应相关.
主要成果:
- 来自油脂,牛脂或黄油的HFD加速了黑色素瘤的生长,而来自子油,棕油或橄油的HFD没有,尽管它们引起了类似的肥胖.
- 基于黄油和棕油的HFD不同影响了自然杀手和CD8T细胞的透和功能.
- 与棕油HFD相比,长链乙卡尼丁被确定为在食黄油HFD的小鼠中丰富的免疫抑制代谢物,与棕油HFD相比.
结论:
- 食脂肪的来源显著影响瘤生长和肥胖的抗瘤免疫力.
- 特定的饮食脂质可以调节瘤微环境和免疫细胞活性.
- 饮食脂肪修改有可能改善肥胖个体的癌症结果.
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