针对威尔姆斯瘤的向治疗:对全球科学活动和协作网络的文献计量研究
Boshen Shu1, Shufeng Zhang1, Jian Gao1
1Department of Pediatric Surgery, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan Province, China.
Discover oncology
|July 27, 2025
概括
这份图书统计分析揭示了威尔姆斯瘤 (WT) 向治疗研究的快速增长,主要由美国主导. 然而,为了在儿童癌症治疗中取得未来的进步,全球合作需要加强.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症治疗方法 癌症治疗方法
- 图书统计分析 图书统计分析
背景情况:
- 威尔姆斯瘤 (神经母细胞瘤) 是最常见的儿科腹部固体瘤,其显著的复发率高达15%.
- 针对性疗法为被诊断为威尔姆斯瘤的患者提供了关键的治疗途径.
研究的目的:
- 在威尔姆斯瘤向治疗中进行文献计量分析,评估全球研究成果和协作网络.
- 确定该领域的关键趋势,有影响力的机构和新兴研究热点.
主要方法:
- 在Web of Science Core Collection (WoSCC) 数据库中对1945年至2024年的出版物进行了全面的文献搜索.
- 使用VOSviewer,Graphpad和Bibliometrix R.包进行了图书法和可视化分析.
主要成果:
- 总共分析了1604篇论文,美国在研究成果方面领先 (572篇论文),哈佛大学是最多产的机构 (122篇论文).
- 杉山H和奥卡Y成为极具影响力的研究人员,杉山H在出版物 (59) 和奥卡Y在共同引用 (382) 中领先.
- 常见的关键词包括"表达"和"威尔姆斯瘤",最近的热点被确定为"lncRNA"",生物标志物"和"microRNA".
结论:
- 研究对威尔姆斯瘤向治疗的兴趣正在迅速扩大,突出显示了其日益重要的意义.
- 目前的研究集中在发达地区,这表明需要加强国际合作和翻译研究,以加快进步.
相关概念视频
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
02:49Cancer Therapies
8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K
02:50Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K