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接种COVID-19XBB.1.5疫苗后的耳风险:一个自我控制的案例系列研究研究

Stanley Xu¹, Lina S Sy², Vennis Hong²

¹Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA.

|July 27, 2025

概括

接种COVID-19 XBB.1.5疫苗,单独或与流感疫苗一起,没有显示 tinnitus 的风险增加. 这项研究提供了关于COVID-19疫苗对耳的安全性的令人放心的证据.

科学领域:

疫苗学疫苗学疫苗学
流行病学流行病学
公共卫生公共卫生

背景情况:

人们仍然担心COVID-19疫苗接种和耳之间存在潜在联系,尽管之前的研究没有发现明显的关联.
这项研究研究了COVID-19 XBB.1.5疫苗后的耳风险,包括与流感疫苗联合使用时.

研究的目的:

评估接种COVID-19 XBB.1.5疫苗后发生耳风险.
评估与流感疫苗同时使用是否会影响耳风险.

主要方法:

采用了事件依赖的自控案例系列 (SCCS) 设计.
分析了2023年9月1日至2024年3月31日期间凯泽永久南加州12岁以上的个体的数据.
该研究检查了疫苗接种后首次出现的耳声和一年内首次出现的耳声事件,并将风险间隔 (1-14天和1-28天) 与控制间隔进行比较.

主要成果:

在接种疫苗后14天或28天内没有观察到首次耳风险增加 (RI分别为0.78 [95%CI:0.67-0.90]和0.87 [95%CI:0.78-0.96]).
根据年龄和流感疫苗联合使用的子组分析显示,耳风险没有显著增加.
在任何分析中,对于一年内首次出现的耳声没有发现显著增加的风险.

结论:

这些发现表明,在接种COVID-19 XBB.1.5疫苗后,耳声的风险没有增加.
这项研究提供了关于COVID-19疫苗对耳发育的安全性的令人放心的证据.

关键词:

在COVID-19 XBB.1.5病毒中.接种COVID-19疫苗的时间联合管理联合管理接种流感疫苗接种疫苗自主控制的案例系列.声 (Tinnitus) 是一种听力障碍.

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